Saint Andrew - Roanoke, Est. 1890 Beginning at the juncture of the Botetourt, Bedford, and Roanoke County lines, south and west along the Roanoke-Bedford and Roanoke-Franklin County lines to US-220, northeast on US-220 - which becomes US-220 Business - to 3rd Street in Roanoke City, north on 3rd Street to the Norfolk Southern rails, west along the Norfolk Southern rails to the Roanoke-Salem city line, south and west along the Roanoke-Salem line to the Roanoke River, west along the Roanoke River to Mason Creek, north along Mason Creek to Interstate 81, north on I-81 to the Roanoke Botetourt County line, southeast along the Roanoke-Botetourt County line to its intersection with the Bedford County line, which is the starting point.